Nona Biosciences

Nona Biosciences is a global biotechnology company committed to cutting edge technology innovations, and providing a total solution for partners worldwide, from academies, biotech startups to biopharma giants. The integrated antibody discovery services range from antigen preparation, animal immunization, single B cell screening, to antibody lead generation and engineering, developability assessment and pharmacological evaluation, leveraging the advantages of Harbour Mice® platforms and the experienced therapeutic antibody discovery team.


Harbour Mice® generates fully human monoclonal antibodies in two heavy and two light chains (H2L2) format, as well as heavy chain only (HCAb) format. Integrating Harbour Mice® and a single B cell cloning platform, Nona Biosciences is focused on driving global inventions of transformative next-generation drugs by diversified partnership strategies. The values of the antibody discovery platforms and flexible partnership models have been well validated.

Our Mission

Leveraging industrial leading Harbour Mice® platforms, Nona Biosciences is committed to providing a total solution for biotech and pharmaceutical companies from Idea to IND (I to ITM).


Core Technology:
Harbour Mice®
Clinically Validated of Fully Human
Antibody Platforms

A unique platform to generate human heavy chain only antibodies naturally suitable for making bispecific antibodies

  • Unique fully human sequence HCAb
  • Versatile for broad applications, incl. CART, ADC, mRNA and diagnostic imaging tool etc.

Transgenic mice bearing human preferential immunoglobulin genes with robust B cell development & antibody maturation

  • Robust and highly efficient
  • Global IP
  • Clinically validated


Next-Generation Therapeutic Modalities
  • HCAb +antibody/protein
  • HCAb +payload
  • HCAb +cell
  • HCAb +nanoparticle

Discovery Solution
A one-stop solution for therapeutic antibody
discovery, engineering and development.
  • Antigen Design,
    Production & Cell
    Line Generation
  • In Vitro Functional
    Assays Establishment
  • Harbour Mice®
    H2L2, HCAb<
  • Beacon® Single B
    Cell Screening
  • Display Technologies
    Phage, Yeast & Mammalian Cell (Optional)
  • Recombinant
  • In Vitro
  • In Vivo PK/PD
    Efficacy Study
  • Developability
  • Antibody Engineering
    Affinity Maturation, Liability Engineering, Fc Engineering
  • Bispecific
Flexible Business Models

We are here for you, embracing and supporting
brilliant ideas, and building your corridor to success.

Versatile Business Solutions to Maximize the Value of Customers

H2L2 and HCAb Harbour Mice® Platforms have been well
validated and widely used in the industry & academia.

1 Broadway, Cambridge, MA 02142
(+1) 617-4108904
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