Resources
- An anti-CTLA-4 heavy chain–only antibody with enhanced Treg depletion shows excellent preclinical efficacy and safety profile
Gan X, Shan Q, Li H, Janssens R, Shen Y, He Y, Chen F, van Haperen R, Drabek D, Li J, Zhang Y, Zhao J, Qin B, Jheng MJ, Chen V, Wang J, Rong Y, Grosveld F. An anti-CTLA-4 heavy chain-only antibody with enhanced Treg depletion shows excellent preclinical efficacy and safety profile. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2200879119. doi: 10.1073/pnas.2200879119. Epub 2022 Aug 4. PMID: 35925889.
- A Transgenic Heavy Chain IgG Mouse Platform as a Source of High Affinity Fully Human Single-Domain Antibodies for Therapeutic Applications
Drabek D, Janssens R, van Haperen R, Grosveld F. A Transgenic Heavy Chain IgG Mouse Platform as a Source of High Affinity Fully Human Single-Domain Antibodies for Therapeutic Applications. Methods Mol Biol. 2022;2446:121-141. doi: 10.1007/978-1-0716-2075-5_6. PMID: 35157271.
- Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes
Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes
- Expression Cloning and Production of Human Heavy-Chain-Only Antibodies from Murine Transgenic Plasma Cells
Drabek D, Janssens R, de Boer E, et al. Expression Cloning and Production of Human Heavy-Chain-Only Antibodies from Murine Transgenic Plasma Cells. Front Immunol. 2016;7:619.
- Heavy chain-only antibodies and tetravalent bispecific antibody neutralizing Staphylococcus aureus leukotoxins
Drabek D, Janssens R, de Boer E, et al. Expression Cloning and Production of Human Heavy-Chain-Only Antibodies from Murine Transgenic Plasma Cells. Front Immunol. 2016;7:619.
- Generation of heavy-chain-only antibodies in mice
Janssens R, Dekker S, Hendriks RW, Panayotou G, van Remoortere A, San JK, et al.Generation of heavy-chain-only antibodies in mice. Proc Natl Acad Sci U S A. 2006;103(41):15130–5