Nona Biosciences Announces Latest Business Progress with Kelun Biotech
CAMBRIDGE, MA— December 23, 2022

Nona Biosciences, a wholly-owned subsidiary of HBM Holdings Limited committed to providing a total solution from Idea to IND (I to ITM), today announces that it has entered into two supplemental agreements to the license agreement with Kelun-Biotech in which Kelun-Biotech is entitled to license two ADC products (product 1 and product 2) jointly developed by the two parties to a licensed independent third party. The supplemental agreement shall take effect upon the agreement between Kelun-Biotech and the third party taking effect.

Pursuant to the supplemental agreements, Nona Biosciences is entitled to receive 30% of the proceeds derives from the two products, including:

Product 1

• Product 1 is a project that Nona Biosciences license Kelun-Biotech to authorize to a third party, and Nona Biosciences is entitled to receive 30% of the upfront payment, milestone payments and tiered royalties.

• The upfront payment of product 1 is US$30 million, and Nona Biosciences is entitled to receive 30% of such payment.

Product 2

• Product 2 is a project that Nona Biosciences license Kelun-Biotech to co-developed with a third party.

• Nona Biosciences is entitled to receive 30% of the upfront payment, milestone payments and tiered royalties of product 2.

Dr. Jingsong Wang, Founder, Chairman, and CEO of Harbour BioMed said: “We are glad to achieve in-depth cooperation with Kelun-Biotech which is also a powerful recognition of our proprietary H2L2 platform. Leveraging the Harbour Mice® platform together with our antibody discovery capabilities, we look forward to helping our partners generate differentiated therapeutic molecules more and better on a global basis.”

About Nona Biosciences

Nona Biosciences (a wholly-owned subsidiary of HBM Holdings, HKEX: 02142) is a global biotechnology company committed to providing a total solution from “Idea to IND” (“I to ITM”), ranging from target validation and antibody discovery through preclinical research. The integrated antibody and antibody-related discovery services with multiple modalities range from antigen preparation, animal immunization, single B cell screening, to antibody lead generation and engineering, developability assessment and pharmacological evaluation, leveraging advantages of Harbour Mice® platforms and the experienced

therapeutic antibody discovery

team.

Harbour Mice® generates fully human monoclonal antibodies in classical two light and two heavy chain (H2L2) format, and heavy chain only (HCAb) format. Integrating Harbour Mice® and a single B cell cloning platform, Nona Biosciences is focused on driving global inventions of transformative next-generation drugs. More information, please check www.nonabio.com